辛洪亮

来源:必威官网登录 发布时间:2017-05-04浏览次数:2722

辛洪亮,男,中共党员,副教授,药剂学博士,国际控释协会(CRS)中国分会会员。Biomaterials, International Journal of Pharmaceutics, Journal of Materials, Colloids and Surfaces B: Biointerfaces, Drug Development and Industrial Pharmacy等杂志通讯审稿专家。
个人简介】2011年7月毕业于复旦大学药学院并获得药剂学博士学位,同年进入南医大药学院工作。入选2015年南京医科大学优秀中青年教师计划,2016江苏省“青蓝工程”优秀青年教师计划。2016年江苏省“优青”获得者,2015.11-2016.11赴美国北卡罗莱纳大学教堂山分校(UNC)&北卡罗莱纳州立大学联合生物医学工程系访学。
研究方向】近年来主要从事靶向递药系统与响应性药物载体的研究,尤其是在中枢神经系统靶向和肿瘤靶向智能递送载体方面具有丰富的研究经验。作为项目负责人,主持国家自然科学基金面上项目1项,国家自然科学基金青年基金1项,江苏省“优青”基金1项,江苏省自然科学基金青年基金1项,江苏省高校自然科学基金面上项目1项,参与国家自然科学基金、江苏省自然科学基金等各类纵向课题6项。在国内外学术期刊上公开发表科研论文三十余篇,其中SCI收录26篇,累积影响因子超过170,研究成果曾获得“中国药学会优秀论文二等奖”、“上海市药学会论文报告会优秀论文一等奖”、“首届长三角药物制剂发展论坛优秀论文一等奖” “中国药物制剂大会优秀墙报交流奖”等奖项。申请发明专利7项,其中授权3项。
联系方式 】电话:025-86868479; E-mail:xhl@njmu.edu.cn
主要代表作 】
1. Jiang Yan, Wang Xiuzhen, Liu Xin, Lv Wei, Zhang Hongjuan, Li Xinrui, Xin Hongliang* , Xu Qunwei*. Enhanced Antiglioma Efficacy of Ultrahigh Loading Capacity Paclitaxel Prodrug Conjugate Self-Assembled Targeted Nanoparticles. ACS Appl Mater Interfaces. 2017, 9(1):211-217

2. Zhao Yue , Jiang Yan, Wei Lv, Wang Zhongyuan, Lv Lingyan, Wang Baoyan, Liu Xin, Liu Yang, Hu Quanyin, Sun Wujin, Xu Qunwei*, Xin Hongliang*, Gu Zhen. Dual targeted nanocarrier for brain ischemic stroke treatment. Journal of controlled release 2016, 233:64-71

3. Jiang Yan, Lv Lingyan, Shi Huihui, Hua Yabing, Lv Wei, Wang Xiuzhen, Xin Hongliang*, Xu Qunwei? PEGylated Polyamidoamine dendrimer conjugated with tumor homing peptide as a potential targeted delivery system for glioma. Colloids and Surfaces B: Biointerfaces 2016, 147:242-249

4. Lv Lingyan, Jiang Yan, Liu Xin, Wang Baoyan, Lv Wei, Zhao Yue, Shi Huihui, Hu Quanyin,  Xin Hongliang*, Xu Qunwei*, Gu Zhen. Enhanced Antiglioblastoma Efficacy of Neovasculature and Glioma Cells Dual Targeted Nanoparticles. Mol. Pharmaceutics 2016, 13(10): 3506?3517

5. Wang, Baoyan; Lv, Lingyan; Wang, Zhi; Jiang,Yan; Lv,Wei; Liu,Xin; Wang, Zhongyuan; Zhao, Yue; Xin, Hongliang*; Xu, Qunwei*. Improved anti-glioblastoma efficacy by IL-13Rα2 mediated copolymer nanoparticles loaded with paclitaxel. Sci Rep. 2015 Nov 16;5:16589

6. Wang, Zhongyuan;  Zhao,Yue; Jiang,Yan;  Lv,Wei; Wu, Lin; Wang, Baoyan; Lv, Lingyan; Xu, Qunwei;* Xin, Hongliang* Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system. Sci Rep. 2015 Jul 29;5:12651

7. Wang Baoyan, Lv Lingyan, Wang Zhongyuan, Zhao Yue, Wu Lin, Fang Xiaoling, Xu Qunwei*, Xin, Hongliang* Nanoparticles functionalized with Pep-1 as potential glioma targeting delivery system via Interleukin 13 receptor 2-mediated endocytosis. Biomaterials 2014, 35(22): 5897-5907

8. Jiang Xinyi, Xin, Hongliang; (Co-First Author), Gu, Jijin; Du, Fengyi; Feng, Chunlai; Xie, Yike; Fang, Xiaoling*. Enhanced Antitumor Efficacy by d-Glucosamine-Functionalized and Paclitaxel-Loaded Poly(Ethylene Glycol)-Co-Poly(Trimethylene Carbonate) Polymer Nanoparticles. J Pharm Sci. 2014, 103(5): 1487-1496

9. Jiang, Xinyi; Xin, Hongliang; (Co-First Author), Ren, Qiuyue; Gu, Jijin; Zhu, Lingjun; Du, Fengyi; Feng, Chunlai; Xie, Yike; Sha, Xianyi; Fang, Xiaoling*. Nanoparticles of 2-deoxy-d-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment. Biomaterials 2014, 35(1): 518-529

10. Li Jing, Wu Ling, Wu Weijun, Wang Baoyan, Wang Zhongyuan, Xin Hongliang*, Xu Qunwei*. A potential carrier based on liquid crystal nanoparticles for ophthalmic delivery of pilocarpine nitrate. Int. J. Pharm. 2013, 455(1-2):75-84.

11. Wu Weijun, Li Jing, Wu Ling, Wang Baoyan, Wang Zhongyuan, Xu Qunwei*, Xin Hongliang*.Ophthalmic delivery of brinzolamide by liquid crystalline nanoparticles: in vitro and in vivo evaluation. AAPS Pharm SciTech 2013, 14(3):1063-1071.

12. Xin, Hongliang; Sha, xianyi; Jiang, xinyi; Zhang, Wei; Chen, liangcen; Fang, Xiaoling*. Anti-glioblastoma efficacy and safety of paclitaxel-loading Angiopep-conjugated dual targeting PEG-PCL nanoparticles Biomaterials 2012, 33(32): 8167-8176.

13. Xin, Hongliang; Sha, xianyi; Jiang, xinyi; Chen, liangcen; kitty, Law; Gu, jijin; Chen,yanzuo; Wang, xiao; Fang, Xiaoling*. The brain targeting mechanism of Angiopep-conjugated poly(ethylene glycol)- co-poly(ε-caprolactone) nanoparticles Biomaterials 2012, 33(5): 1673-1681

14. Xin, Hongliang; Jiang, xinyi; Gu, jijin; Sha, xianyi; Chen, liangcen; kitty, Law; Chen,yanzuo; Wang, xiao; Jiang, ye; Fang, Xiaoling*. Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles as dual-targeted drug delivery system for brain glioma. Biomaterials 2011, 32(18): 4293-4305

15. Xin, Hongliang; Chen, liangcen; Gu, jijin; Ren, xiaoqing; Zhang, wei; Luo, jieqi; Chen, yanzuo; Jiang, xinyi; Sha, xianyi; Fang, xiaoling*. Enhanced anti-glioblastoma efficacy by PTX-loaded PEGylated poly(ε-caprolactone) nanoparticles: In vitro and in vivo evaluation. Int. J. Pharm. 2010, 402: 238-247


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